What question did this study set out to answer?

To review the evolving roles of matrix metalloproteinases (MMPs) across normal developmental processes, tissue homeostasis, and cancer pathogenesis.

February 3, 2015Matrix BiologyOpen Access

Matrix metalloproteinases in stem cell regulation and cancer

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To review the evolving roles of matrix metalloproteinases (MMPs) across normal developmental processes, tissue homeostasis, and cancer pathogenesis.
Synthesized historical and contemporary findings regarding MMP biological functions across developmental biology, stem cell biology, and oncology.
Evaluated classical collagenolytic actions alongside non-proteolytic signaling mechanisms that influence disease progression and therapeutic resistance.
MMPs facilitate tumor invasion and metastasis through extracellular matrix degradation while also directing cell signaling networks essential for tissue homeostasis.
Evidence demonstrates that MMPs can exert regulatory effects independently of their catalytic cleavage activity via non-proteolytic mechanisms.
Context-dependent functional modes provide a mechanistic basis to re-evaluate MMPs as viable therapeutic targets and optimize inhibitor design.

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Implication

Narrative review uncovers multifaceted functions of matrix metalloproteinases in development and tumors, highlighting new opportunities for targeted inhibitor design.

Cite This Study

Kessenbrock et al. (2015) studied this question.

synapsesocial.com/papers/69dc6b8824e766dc313592ab https://doi.org/10.1016/j.matbio.2015.01.022

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Implication

Narrative review uncovers multifaceted functions of matrix metalloproteinases in development and tumors, highlighting new opportunities for targeted inhibitor design.

Matrix metalloproteinases in stem cell regulation and cancer

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Discussion

Implication

Cite This Study

Matrix metalloproteinases in stem cell regulation and cancer

Key Points

Discussion

Implication

Cite This Study

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