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October 1, 2004Radiology

Detection of Synovial Macrophages in an Experimental Rabbit Model of Antigen-induced Arthritis: Ultrasmall Superparamagnetic Iron Oxide–enhanced MR Imaging

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Population

Experimental rabbit model of antigen-induced arthritis

Design

Preclinical

Authors

ALA.M. LutzSpital Thurgau (Switzerland)CSChristian A. SeemayerGalapagos (Belgium)CCClaire CorotUniversité Paris-Sud

Discussion

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Implication

USPIO-MR feasible for macrophage imaging in rabbit arthritis; leaves open human translation.

Structured PICO

P
Population
Experimental rabbit model of antigen-induced arthritis
I
Intervention
Ultrasmall Superparamagnetic Iron Oxide (USPIO)-enhanced MR imaging at 1.5 T
O
Outcome
Depiction of USPIO uptake in phagocytic-active macrophagessurrogate

USPIO-enhanced MR imaging at 1.5 T is capable of detecting synovial macrophages in a rabbit model of antigen-induced arthritis.

Cite This Study

Lutz et al. (2004) studied this question.

synapsesocial.com/papers/69dc755924e766dc313593b1https://doi.org/10.1148/radiol.2331031402

Topics

Sermorelin
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