Discontinuation of antidepressants: Is there a minimum time on treatment that will reduce relapse risk?

Xiaoqin Liu; Natalie C. Momen; Nina M. Molenaar; Anna‐Sophie Rommel; Veerle Bergink; Trine Munk‐Olsen

doi:10.1016/j.jad.2021.04.045

May 6, 2021Journal of Affective DisordersOpen Access

Discontinuation of antidepressants: Is there a minimum time on treatment that will reduce relapse risk?

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Key Points

To determine whether a minimum duration of antidepressant treatment reduces the risk of depressive relapse following medication discontinuation.
Evaluated outcomes associated with different durations of antidepressant therapy prior to treatment cessation.
A minimum duration of 10 to 12 months of antidepressant treatment is preferable to reduce the risk of relapse after discontinuation.

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Implication

Clinical evaluation finds reduced relapse risk following at least 10 to 12 months of antidepressant treatment, indicating an optimal minimum duration before discontinuation.

Abstract

Based on our findings, a minimum of 10-12 months of treatment appears to be preferable if there is concern about relapse after discontinuation.

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Liu et al. (2021) studied this question.

synapsesocial.com/papers/69dc83c47873f5f05b133465 https://doi.org/10.1016/j.jad.2021.04.045

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Discontinuation of antidepressants: Is there a minimum time on treatment that will reduce relapse risk?

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Discontinuation of antidepressants: Is there a minimum time on treatment that will reduce relapse risk?

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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