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April 13, 2026Journal of Translational Medicine4 citationsOpen Access

Mitochondrial dysfunction in neonatal brain injury: from molecular mechanisms to therapeutic interventions

CTC TengJWJianjie WeiLZLina Zhu

Key Points

  • This review aims to connect mitochondrial dysfunction patterns to neonatal brain injury types, enhancing intervention strategies.
  • Review of existing literature on mitochondrial dysfunction and neonatal brain injury
  • Identification of specific dysfunction patterns associated with injury stages
  • Discussion of potential mitochondria-targeted therapies
  • Establishment of a framework for recognizing high-risk infants
  • Refinement of understanding regarding the pathophysiology of neonatal brain injury
  • Highlighting possible interventions to improve neurological outcomes

Abstract

By linking specific patterns of mitochondrial dysfunction to distinct forms and stages of neonatal brain injury, this review provides a mechanistic framework for identifying high‑risk infants, refining pathophysiological understanding, and guiding the rational development of mitochondria‑targeted interventions aimed at improving neurological outcomes in vulnerable newborns.

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Cite This Study

Teng et al. (2026) studied this question.

synapsesocial.com/papers/69dc87ea3afacbeac03e9edfhttps://doi.org/10.1186/s12967-026-08104-2
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