The effect of oleanolic acid on ischemia-reperfusion damage in the rat inferior epigastric artery skin flap model

Key Points

• To investigate the protective effects of oleanolic acid on ischemia-reperfusion damage in a rat model.
• Experimental model using rat inferior epigastric artery skin flaps
• Administration of oleanolic acid prior to ischemia
• Assessment of oxidative stress markers and tissue viability
• Oleanolic acid treatment reduced markers of oxidative stress
• Improved tissue viability observed in treated groups
• Significant decrease in ischemia-reperfusion injury as compared to control