A case of solitary plasmacytoma of mandible with a review on plasma cell neoplasms of oral cavity

Plasma cell neoplasms are malignant proliferations of terminally differentiated plasma cells which produce monoclonal immunoglobulins.It is mostly seen in adulthood and usually occurs over the age of fifty.The solitary bone plasmacytoma is a unifocal form of the disease and is believed to be a precursor to multiple myeloma which is the disseminated form.Extramedullary plasmacytoma has also been described in the mucosa of upper aerodigestive tract and has less propensity to develop into multiple myeloma.Histopathology of all forms of plasma cell neoplasms consists of monotypic infiltrates of cells with plasma cell profile.Oral involvement is rare and oral lesions account for only four percent of solitary plasmacytomas.A case report of a 69 year old female patient with solitary plasmacytoma involving the posterior mandibular region is presented here, along with a discussion on the clinical and pathological aspects of plasma cell neoplasms.