What question did this study set out to answer?

This study aims to describe the clinical presentation and identify factors affecting outcomes in CNS tuberculosis.

April 13, 2026Annals of Indian Academy of Neurology0 citationsOpen Access

Clinical Profile and Prognostic Determinants in Central Nervous System Tuberculosis: An Observational Study from a Tertiary Neurology Centre in India

SSSuman Kumar SahuInstitute of Human Behaviour and Allied Sciences RDRajinder K. DhamijaInstitute of Human Behaviour and Allied Sciences SMSonali MaheshwariInstitute of Human Behaviour and Allied Sciences

Key Points

This study aims to describe the clinical presentation and identify factors affecting outcomes in CNS tuberculosis.
Analyzed clinical profiles of individuals with CNS tuberculosis at a tertiary neurology center.
Assessed neuroimaging abnormalities associated with the disease.
Evaluated relationships between clinical features and patient outcomes.
Young adults mainly affected, presenting with meningeal features and varied neuroimaging results.
Limited microbiological confirmation highlights reliance on clinical diagnoses.
Poor outcomes linked to advanced age, prolonged illness, and specific neurological complications.

Abstract

CNS TB in our cohort predominantly affected young adults and presented with classical meningeal features and diverse neuroimaging abnormalities. Microbiological confirmation remained limited, underscoring reliance on clinical-radiological diagnosis. Poor outcome was associated with increasing age, longer duration of illness, cranial neuropathy, hydrocephalus, and paradoxical reaction.

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