Systematic review compares lesion clearance rates and side effects of therapies in actinic keratosis, suggesting need for standardized protocols.
Lesion clearance may depend on location. It is comparable for head and face lesions, while data from one trial suggests cryotherapy may be better for extremity lesions. PDT is associated with a higher occurrence of pain/burning, while cryotherapy leads to more vesicles/blisters. Future research should focus on standardized protocols, including blinded post-treatment assessments to improve reliability and minimize bias.
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Aldraibi et al. (2026) studied this question.
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