What question did this study set out to answer?

Identify clinical and biological variables that predict survival after relapse in patients diagnosed with neuroblastoma.

July 18, 2011Journal of Clinical Oncology

Clinical and Biologic Features Predictive of Survival After Relapse of Neuroblastoma: A Report From the International Neuroblastoma Risk Group Project

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Identify clinical and biological variables that predict survival after relapse in patients diagnosed with neuroblastoma.
Analyzed clinical and biologic registry data from the International Neuroblastoma Risk Group Project.
Assessed the prognostic impact of patient age, tumor stage, MYCN amplification status, and time to first relapse on postrelapse outcomes.
Age, disease stage, MYCN status, and time to first relapse significantly predict postrelapse survival.
Identified risk factors establish a clinical framework to inform trial designs and patient selection when testing novel therapeutic agents.

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Implication

Cohort study reveals significant predictors of postrelapse survival in neuroblastoma, suggesting improved risk stratification for clinical trials of novel therapies.

Cite This Study

London et al. (2011) studied this question.

synapsesocial.com/papers/69dc8ae7a5c75be4cfe52f49 https://doi.org/10.1200/jco.2010.34.3392

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Implication

Cohort study reveals significant predictors of postrelapse survival in neuroblastoma, suggesting improved risk stratification for clinical trials of novel therapies.

Clinical and Biologic Features Predictive of Survival After Relapse of Neuroblastoma: A Report From the International Neuroblastoma Risk Group Project

Key Points

Discussion

Implication

Cite This Study

Clinical and Biologic Features Predictive of Survival After Relapse of Neuroblastoma: A Report From the International Neuroblastoma Risk Group Project

Key Points

Discussion

Implication

Cite This Study

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