What question did this study set out to answer?

Assess the long-term efficacy and safety of R-CHOP induction followed by maintenance rituximab until disease progression in older individuals with mantle cell lymphoma.

December 5, 2019Journal of Clinical OncologyOpen Access

Treatment of Older Patients With Mantle Cell Lymphoma (MCL): Long-Term Follow-Up of the Randomized European MCL Elderly Trial

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Assess the long-term efficacy and safety of R-CHOP induction followed by maintenance rituximab until disease progression in older individuals with mantle cell lymphoma.
Conducted a mature long-term follow-up of the randomized European MCL Elderly Trial in older individuals with mantle cell lymphoma.
Evaluated maintenance rituximab administered until disease progression, specifically examining treatment extension beyond 2 years.
Long-term outcomes confirm that the superior disease control achieved with R-CHOP followed by rituximab maintenance persists over extended observation.
Continuing rituximab maintenance therapy beyond 2 years remains effective and safe without introducing late toxicities.

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Implication

Randomized trial demonstrates sustained efficacy of extended rituximab maintenance in older patients with mantle cell lymphoma, indicating long-term disease control.

Cite This Study

Kluin‐Nelemans et al. (2019) studied this question.

synapsesocial.com/papers/69dca0a7a5c75be4cfe533cd https://doi.org/10.1200/jco.19.01294

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Implication

Randomized trial demonstrates sustained efficacy of extended rituximab maintenance in older patients with mantle cell lymphoma, indicating long-term disease control.

Treatment of Older Patients With Mantle Cell Lymphoma (MCL): Long-Term Follow-Up of the Randomized European MCL Elderly Trial

Key Points

Discussion

Implication

Cite This Study

Treatment of Older Patients With Mantle Cell Lymphoma (MCL): Long-Term Follow-Up of the Randomized European MCL Elderly Trial

Key Points

Discussion

Implication

Cite This Study

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