Why the study?
Does telmisartan or the combination of telmisartan and ramipril improve outcomes compared to ramipril in patients with vascular disease or high-risk diabetes?
Population
Patients with vascular disease or high-risk diabetes
Comparison
Telmisartan alone or in combination with ramipril vs Ramipril alone
Design
RCT
Authors
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Telmisartan is a suitable ramipril alternative with less angioedema; confirms no benefit and more harm from dual blockade in high-risk patients.
Does telmisartan or the combination of telmisartan and ramipril improve outcomes compared to ramipril in patients with vascular disease or high-risk diabetes?
Telmisartan is an effective alternative to ramipril with a lower risk of angioedema in high-risk vascular patients, but combining the two agents increases adverse events without added benefit.
The ONTARGET Investigators (2008) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: