Why the study?
Are insulin resistance and metabolic syndrome associated with left ventricular diastolic dysfunction before the onset of overt diabetes?
Are insulin resistance and metabolic syndrome associated with left ventricular diastolic dysfunction before the onset of overt diabetes?
Changes in diastolic function occur early in the diabetic continuum and are independently associated with insulin resistance prior to the onset of overt diabetes.
May inform early risk stratification in prediabetes; extends cross-sectional associations but leaves causality and intervention effects open.
HOMA-IR score and metabolic syndrome were independently associated with LVDD. Changes in diastolic function are already present before the onset of diabetes, being mainly associated with the state of insulin resistance.
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Fontes‐Carvalho et al. (2015) studied this question.
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