Does early or delayed enalapril treatment attenuate acute and chronic cardiac and neuroinflammation after myocardial infarction?
Early enalapril treatment after myocardial infarction attenuates acute cardiac and neuroinflammation, but fails to alleviate chronic neuroinflammation.
Whole-body TSPO PET identifies myocardial macrophage infiltration and neuroinflammation after MI, and altered cardiomyocyte mitochondrial density in chronic heart failure. Improved chronic cardiac outcome by enalapril treatment derives partially from acute anti-inflammatory activity with complementary benefits in later stages. Whereas early ACE inhibitor therapy lowers acute neuroinflammation, chronic alleviation is not achieved by early or delayed ACE inhibitor therapy, suggesting a more complex mechanism underlying recurrent neuroinflammation in ischemic heart failure.
Borchert et al. (Tue,) studied this question.