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July 1, 1984The Journal of PhysiologyOpen Access

Stretch‐activated single ion channel currents in tissue‐cultured embryonic chick skeletal muscle.

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Population

Tissue-cultured embryonic chick pectoral muscle

Comparison

Membrane stretch, exposure to cytochalasin B… vs Unstretched membrane / normal saline (5 mM-K+)

Design

Preclinical

Authors

FGF GuharayUniversity of NottinghamFSFrederick SachsElectrophysiology

Discussion

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Implication

Extends cytoskeletal modulation of stretch-activated channel kinetics in embryonic muscle; leaves open cardiac mechanosensitivity relevance.

Structured PICO

P
Population
Tissue-cultured embryonic chick pectoral muscle
I
Intervention
Membrane stretch, exposure to cytochalasin B, and varying extracellular K+ concentrations
C
Comparator
Unstretched membrane / normal saline (5 mM-K+)
O
Outcome
Ion channel conductance, kinetics, and stretch sensitivitysurrogate

Demonstrates the presence and kinetic properties of a stretch-activated ion channel in embryonic chick skeletal muscle that is modulated by cytoskeletal elements.

Cite This Study

Guharay et al. (1984) studied this question.

synapsesocial.com/papers/69dcc2ecd4d0de07d1133981https://doi.org/10.1113/jphysiol.1984.sp015317
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