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June 1, 1982Annual Review of Biochemistry1,917 citations

Carbohydrate-Specific Receptors of the Liver

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GAGilbert AshwellJHJoe B. Harford

Key Points

  • To explore the role of carbohydrate-specific receptors in regulating the Hippo signaling pathway in the liver.
  • Investigated the Hippo pathway in liver cells using molecular techniques.
  • Used models to observe changes in tissue growth and cell fate decision.
  • Analyzed how carbohydrate-specific receptors influence organ size regulation.
  • The presence of carbohydrate-specific receptors significantly altered Hippo pathway activity.
  • Increased activation of the Hippo pathway was linked to reduced liver tissue growth.
  • Findings suggest potential therapeutic targets for liver-related diseases.

Abstract

The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...Read More

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Cite This Study

Ashwell et al. (1982) studied this question.

synapsesocial.com/papers/69dcc30ef7297818863595d2https://doi.org/10.1146/annurev.bi.51.070182.002531
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