Ligand‐Controlled Regiodivergent Palladium‐Catalyzed Decarboxylative Allylation Reaction to Access α,α‐Difluoroketones

Abstract α,α‐Difluoroketones possess unique physicochemical properties that are useful for developing therapeutics and probes for chemical biology. To access the α‐allyl‐α,α‐difluoroketone substructure, complementary palladium‐catalyzed decarboxylative allylation reactions were developed to provide linear and branched α‐allyl‐α,α‐difluoroketones. For these orthogonal processes, the fluorination pattern of the substrate enabled the ligands to dictate the regioselectivity of the transformations.