Reference profiling reveals immunophenotypic differentiation shifts in human bone marrow, indicating a streamlined screening approach for age-related and disease-induced changes.
Although alternative immunostainings can be used (e.g., including NK- and T-cell markers), we feel that the selected six stainings represent a comprehensive and easy screening phase for quick identification of shifts in the composition of the studied differentiation lineages, reflecting age-related changes or disease-induced BM abnormalities.
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Lochem et al. (2004) studied this question.
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