Prenatal diagnosis of left isomerism relies on specific markers like viscerocardiac heterotaxy and heart block, which also strongly influence mortality and long-term outcomes.
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May aid prognostic counseling in left isomerism; leaves open prospective validation of diagnostic markers and interventions.
Prenatal diagnosis of left isomerism is feasible, with high accuracy. Important diagnostic pointers are viscerocardiac heterotaxy, complex cardiac malformations, heart block, and interruption of the inferior vena cava. The mortality in fetuses and neonates is high in the presence of heart block and hydrops, whereas the cardiac defects influence the long-term outcome.
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Berg et al. (2005) studied this question.
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