Why the study?
Does induced hyperglycemia and hyperinsulinemia increase platelet activation and monocyte TF expression in healthy subjects?
Does induced hyperglycemia and hyperinsulinemia increase platelet activation and monocyte TF expression in healthy subjects?
Hyperglycemia and hyperinsulinemia promote a procoagulant and proinflammatory state in healthy individuals, which may contribute to acute vascular events and atherogenesis.
Answers are grounded in this paper and cite their sources.
May promote prothrombotic state during hyperglycemia; leaves open clinical relevance in diabetes.
Hyperglycemia-hyperinsulinemia in healthy individuals induced platelet activation and monocyte TF expression promoting a procoagulant and proinflammatory state that may contribute to acute vascular events and atherogenesis. Platelet responsiveness to activation with ADP or SFLLRN appears not to be altered by hyperglycemia-hyperinsulinemia.
No takes yet. Share an insight, caveat, or question.
Vaidyula et al. (2006) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: