Does induced hyperglycemia and hyperinsulinemia increase platelet activation and monocyte TF expression in healthy subjects?
Hyperglycemia and hyperinsulinemia promote a procoagulant and proinflammatory state in healthy individuals, which may contribute to acute vascular events and atherogenesis.
Hyperglycemia-hyperinsulinemia in healthy individuals induced platelet activation and monocyte TF expression promoting a procoagulant and proinflammatory state that may contribute to acute vascular events and atherogenesis. Platelet responsiveness to activation with ADP or SFLLRN appears not to be altered by hyperglycemia-hyperinsulinemia.
Vaidyula et al. (Sun,) studied this question.