Key result
Subcutaneous fat shows greater angiogenic capacity than visceral fat, but impairs with obesity and insulin resistance.
Why the study?
The capacity of subcutaneous adipose tissue to expand its capillary network and its relation to morbid obesity and insulin resistance was unclear.
Impaired subcutaneous adipose tissue angiogenesis in morbid obesity correlates with insulin resistance, potentially contributing to metabolic disease pathogenesis.
Answers are grounded in this paper and cite their sources.
May implicate subcutaneous angiogenesis defects in obesity-related insulin resistance; leaves open whether vascular modulation alters metabolic outcomes.
These data imply that subcutaneous adipose tissue has a higher capacity to expand its capillary network than visceral tissue, but this capacity decreases with morbid obesity. The decrease correlates with insulin resistance, suggesting that impairment of subcutaneous adipose tissue angiogenesis may contribute to metabolic disease pathogenesis.
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Gealekman et al. (2011) studied this question. Subcutaneous adipose tissue has a higher capacity for angiogenesis than visceral tissue, but this capacity decreases with morbid obesity and correlates with insulin resistance.
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