Impaired subcutaneous adipose tissue angiogenesis in morbid obesity correlates with insulin resistance, potentially contributing to metabolic disease pathogenesis.
These data imply that subcutaneous adipose tissue has a higher capacity to expand its capillary network than visceral tissue, but this capacity decreases with morbid obesity. The decrease correlates with insulin resistance, suggesting that impairment of subcutaneous adipose tissue angiogenesis may contribute to metabolic disease pathogenesis.
Gealekman et al. (Tue,) studied this question.