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October 18, 1999The Journal of Experimental MedicineOpen Access

Compromised Ox40 Function in Cd28-Deficient Mice Is Linked with Failure to Develop Cxc Chemokine Receptor 5–Positive Cd4 Cells and Germinal Centers

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Authors

LWLucy S. K. WalkerHealthcare Quality Improvement PartnershipAGAdam Gulbranson‐JudgeUniversity of BirminghamSFSarah FlynnMemorial University of Newfoundland

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Walker et al. (1999) studied this question.

synapsesocial.com/papers/69dcc70ac099bcfdbb1337b9https://doi.org/10.1084/jem.190.8.1115
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mice transgenic for a soluble form of murine CTLA-4 show enhanced expansion of antigen-specific CD4+ T cells and defective antibody production in vivo.1994 · 128 citations
  2. 2CD4 T Cell Cytokine Differentiation: The B Cell Activation Molecule, OX40 Ligand, Instructs CD4 T Cells to Express Interleukin 4 and Upregulates Expression of the Chemokine Receptor, Blr-11998 · 353 citations
  3. 3CD4 T cell traffic control:in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles1999 · 186 citations
  4. 4Ox-40 Ligand: A Potent Costimulatory Molecule for Sustaining Primary CD4 T Cell Responses1998 · 527 citations
  5. 5Antiviral immune responses in CTLA4 transgenic mice1997 · 46 citations