⌘+K

Pulse Explore Clubs Researchers Journals

Home Clubs Explore

October 26, 2012Developmental DynamicsOpen Access

In vitro tendon tissue development from human fibroblasts demonstrates collagen fibril diameter growth associated with a rise in mechanical strength

Andreas Herchenhan Monika L. Bayer René B. Svensson S. Peter Magnusson Michael Kjær

View Full Paper

Ask AI

Bookmark

Share

Abstract

The present study demonstrates that 3D tendon constructs can be formed by isolated human tendon fibroblasts, and when these constructs are subjected to static self-generated tension, the fibrils will grow in size and strength approaching that of adult human tendon in vivo.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Herchenhan et al. (2012) studied this question.

synapsesocial.com/papers/69dcc95ff3d3790cb7133d67 https://doi.org/10.1002/dvdy.23896

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1The initiation of embryonic-like collagen fibrillogenesis by adult human tendon fibroblasts when cultured under tensionOriginal Research · 2010 · 108 citations
2Collagen fibrillogenesis in situ: Fibril segments become long fibrils as the developing tendon maturesOriginal Research · 1997 · 167 citations
3Mechanical properties and collagen cross-linking of the patellar tendon in old and young menCross-Sectional Study · 2009 · 257 citations
4Region-specific mechanical properties of the human patella tendonIn Vitro Study · 2004 · 133 citations
5Growth of Collagen Fibril Seeds from Embryonic Tendon: Fractured Fibril Ends Nucleate New Tip GrowthOriginal Research · 2010 · 21 citations