What question did this study set out to answer?

To determine how local alkaline microenvironments engineered on titanium surfaces influence antibacterial performance and osteogenic cell behaviors.

November 9, 2018ACS Applied Materials & Interfaces

Effect of Local Alkaline Microenvironment on the Behaviors of Bacteria and Osteogenic Cells

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Authors

JTJi TanChinese Academy of Sciences DWDonghui WangKunming University of Science and Technology HCHuiliang CaoEast China University of Science and Technology

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Implication

Experimental study demonstrates that alkaline titanium surfaces inhibit bacteria and enhance osteogenesis, indicating potential for multifunctional bone implants.

Key Points

To determine how local alkaline microenvironments engineered on titanium surfaces influence antibacterial performance and osteogenic cell behaviors.
Fabricated multiple film coatings displaying varying degrees of alkalinity directly onto titanium substrates.
Cultured Gram-positive and Gram-negative bacterial strains on the prepared surfaces to test antibacterial activity.
Assessed cell adhesion, proliferation, and alkaline phosphatase (ALP) activity using bone mesenchymal stem cells and osteoblasts.
Appropriate local surface alkalinity effectively inhibited the growth of Gram-positive and Gram-negative bacteria by inactivating ATP synthesis and inducing oxidative stress.
The alkaline microenvironment promoted the osteogenic differentiation of bone mesenchymal stem cells while elevating the proliferation and ALP activity of osteoblasts.

Cite This Study

Tan et al. (2018) studied this question.

synapsesocial.com/papers/69dcc9bfc099bcfdbb1339a3 https://doi.org/10.1021/acsami.8b15724

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Implication

Experimental study demonstrates that alkaline titanium surfaces inhibit bacteria and enhance osteogenesis, indicating potential for multifunctional bone implants.

Effect of Local Alkaline Microenvironment on the Behaviors of Bacteria and Osteogenic Cells

Discussion

Member takes

Implication

Key Points

Cite This Study

Effect of Local Alkaline Microenvironment on the Behaviors of Bacteria and Osteogenic Cells

Discussion

Member takes

Implication

Key Points

Cite This Study

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