May 1, 1994Journal of VirologyOpen Access

Reverse genetics provides direct evidence for a correlation of hemagglutinin cleavability and virulence of an avian influenza A virus

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Structured PICO

Population

Chickens and chicken embryo fibroblasts (CEF) infected with avian influenza A virus A/turkey/Ontario/7732/66 (H5N9)

Intervention

Hemagglutinin (HA) cleavage mutants generated by reverse genetics (e.g., R-E-T-R, T-R-R-K-K-R, T-T-R-K-K-R, R-K-K-R, R-R-R-K-T-R)

Comparator

Wild-type HA virus (R-R-R-K-K-R)

Outcome

Virulence in chickens (intramuscularly or intranasally/orally inoculated) and HA cleavability in CEFsurrogate

The degree of hemagglutinin cleavability in chicken embryo fibroblasts directly correlates with and predicts the virulence of avian influenza A viruses in chickens.

Discussion

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Implication

HA cleavability predicts avian influenza virulence in chickens; leaves open translation to mammalian hosts or human disease risk.

Cite This Study

Horimoto et al. (1994) studied this question.

synapsesocial.com/papers/69dccb207873f5f05b1341eb https://doi.org/10.1128/jvi.68.5.3120-3128.1994

View Full Paper

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Reverse genetics provides direct evidence for a correlation of hemagglutinin cleavability and virulence of an avian influenza A virus

Structured PICO

Discussion

Implication

Cite This Study

Reverse genetics provides direct evidence for a correlation of hemagglutinin cleavability and virulence of an avian influenza A virus

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider