Mechanistic review uncovers outer membrane permeability dynamics in Gram-negative bacteria, highlighting porin channels as central determinants of antibiotic entry.
Gram-negative bacteria are surrounded by a permeability barrier, the outer membrane (OM).Hydrophilic solutes most often cross the OM through water-filled channels of porins.For example, in Escherichia coli all P-lactams in a study
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Hiroshi Nikaido (1989) studied this question.
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