Why the study?
Do non-clinical repolarization assays predict the risk of drug-induced QT prolongation and Torsades de Pointes in humans?
Population
Non-clinical repolarization assays and human Thorough QT studies
Design
Review
Authors
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May guide early hERG-based QT screening in development; leaves open prospective human validation.
Do non-clinical repolarization assays predict the risk of drug-induced QT prolongation and Torsades de Pointes in humans?
Non-clinical repolarization assays evaluating hERG current inhibition are highly predictive of a drug's potential to cause QT prolongation and Torsades de Pointes in humans.
Robert M. Wallis (2009) studied this question.
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