Modulators of the Kynurenine Pathway of Tryptophan Metabolism: Synthesis and Preliminary Biological Evaluation of ( S )‐4‐(Ethylsulfonyl)benzoylalanine, a Potent and Selective Kynurenine Aminotransferase II (KAT II) Inhibitor

(S)-4-(Ethylsulfonyl)benzoylalanine is a potent and selective inhibitor of kynurenine aminotransferase II (KAT II) with no significant effect on KAT I or other enzymes of the kynurenine pathway. This compound is able to pronouncedly inhibit the formation of kynurenic acid (KYNA) in rat brain. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2452/2006/z500095_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.