Randomized trial reveals targeted mild hypercapnia does not improve six-month neurologic outcomes in comatose cardiac arrest patients, indicating targeted normocapnia remains standard practice.
In patients with coma who were resuscitated after out-of-hospital cardiac arrest, targeted mild hypercapnia did not lead to better neurologic outcomes at 6 months than targeted normocapnia. (Funded by the National Health and Medical Research Council of Australia and others; TAME ClinicalTrials.gov number, NCT03114033.).
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Eastwood et al. (2023) studied this question.
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