The Sugen 5416/hypoxia/normoxia-exposed rat model develops plexiform lesions indistinguishable from human pulmonary arterial hypertension, providing a rigorous model for studying the disease.
Validates Sugen rat model for human PAH lesion studies; leaves open clinical translation pending further validation.
Severe, sustained pulmonary hypertension in a very late stage of the Sugen 5416/hypoxia/normoxia-exposed rat is accompanied by the formation of lesions that are indistinguishable from the pulmonary arteriopathy of human pulmonary arterial hypertension. This unique model provides a new and rigorous approach for investigating the genesis, hemodynamic effects, and reversibility of plexiform and other occlusive lesions in pulmonary arterial hypertension.
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Abe et al. (2010) studied this question.
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