What question did this study set out to answer?

Examine the biological mechanisms governing response, resistance, and toxicity in immune checkpoint therapy while establishing a framework for rational combination regimens.

April 1, 2021Cancer DiscoveryOpen Access

The Next Decade of Immune Checkpoint Therapy

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Authors

PSPadmanee SharmaWest Virginia University BSBilal A. SiddiquiThe University of Texas MD Anderson Cancer Center SASwetha AnandhanThe University of Texas MD Anderson Cancer Center

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Implication

Review reveals mechanisms of resistance and toxicity in cancer immunotherapy, highlighting rational combination therapies to improve patient survival.

Key Points

Examine the biological mechanisms governing response, resistance, and toxicity in immune checkpoint therapy while establishing a framework for rational combination regimens.
Synthesized findings across clinical and basic oncology research evaluating immune checkpoint therapies.
Analyzed pathways driving primary and adaptive resistance as well as immune-related adverse events.
Integrated reverse translational approaches to identify viable targets for future clinical trial designs.
Immune checkpoint therapy induces durable antitumor responses and improves survival, but clinical efficacy remains restricted to limited subsets of cancer patients.
Rational combination therapies overcome primary and adaptive resistance mechanisms but are associated with elevated risks of immune-mediated toxicities.
Integrating reverse translational science optimizes patient selection and guides candidate selection for future clinical trials.

Cite This Study

Sharma et al. (2021) studied this question.

synapsesocial.com/papers/69dce5fe854f360ad6359582 https://doi.org/10.1158/2159-8290.cd-20-1680

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Implication

Review reveals mechanisms of resistance and toxicity in cancer immunotherapy, highlighting rational combination therapies to improve patient survival.

The Next Decade of Immune Checkpoint Therapy

Discussion

Member takes

Implication

Key Points

Cite This Study

The Next Decade of Immune Checkpoint Therapy

Discussion

Member takes

Implication

Key Points

Cite This Study

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