June 8, 2018Nature GeneticsOpen Access

Multi-ethnic genome-wide association study for atrial fibrillation

View Full Paper

Ask AI

Bookmark

Population

More than half a million individuals, including 65,446 with atrial fibrillation.

Design

Meta-analysis

Authors

CRCarolina RoselliElectrophysiology MCMark ChaffinHeart Failure / Cardiomyopathy LWLu‐Chen WengElectrophysiology

Discussion

Member takes

Implication

Expands AF genetic architecture substantially; extends biological pathway insights but leaves clinical translation open.

Structured PICO

Population

More than half a million individuals, including 65,446 with atrial fibrillation (multi-ethnic combined-ancestry and European-specific cohorts).

Intervention

Genome-wide association study (GWAS) meta-analysis, RNA-sequencing, and expression quantitative trait locus analyses

Outcome

Identification of genetic loci significantly associated with atrial fibrillationsurrogate

This large-scale GWAS meta-analysis identified 97 genetic loci associated with atrial fibrillation, expanding our understanding of the biological pathways underlying the disease.

Cite This Study

Roselli et al. (2018) studied this question.

synapsesocial.com/papers/69dcf7eb0de68e8319e53c50 https://doi.org/10.1038/s41588-018-0133-9

Topics

Atrial fibrillation Persistent AF management

View Full Paper

Ask AI

Bookmark

Multi-ethnic genome-wide association study for atrial fibrillation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Multi-ethnic genome-wide association study for atrial fibrillation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider