Sympathetic neural mechanisms in obstructive sleep apnea.
Why the study?
Does CPAP reduce sympathetic nerve activity and blood pressure in patients with obstructive sleep apnea?
Population
10 patients with obstructive sleep apnea, 10 age- and sex-matched control subjects, and 5 obese subjects…
Comparison
Continuous positive airway pressure in a subset… vs Control subjects and baseline measurements
Design
Case-control
Authors
Discussion
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Implication
May inform CPAP decisions in OSA-related hypertension; leaves open effects on cardiovascular outcomes in RCTs.
Structured PICO
Does CPAP reduce sympathetic nerve activity and blood pressure in patients with obstructive sleep apnea?
P
Population
10 patients with obstructive sleep apnea, 10 age- and sex-matched control subjects, and 5 obese subjects without a history of sleep apnea
I
Intervention
Continuous positive airway pressure (CPAP) in a subset of 4 patients
C
Comparator
Control subjects (healthy matched and obese) and baseline measurements (wakefulness vs. sleep)
O
Outcome
Blood pressure, heart rate, sympathetic nerve activity, and polysomnography during wakefulness and sleepsurrogate
Obstructive sleep apnea is associated with elevated sympathetic nerve activity and blood pressure that worsen during sleep but can be attenuated by CPAP therapy.
Cite This Study
Somers et al. (1995) studied this question.