What question did this study set out to answer?

To evaluate the safety and efficacy of oral ivermectin, alone or combined with doxycycline, in accelerating virological clearance in adults hospitalized with mild COVID-19.

December 2, 2020SHILAP Revista de lepidopterologíaOpen Access

A five-day course of ivermectin for the treatment of COVID-19 may reduce the duration of illness

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To evaluate the safety and efficacy of oral ivermectin, alone or combined with doxycycline, in accelerating virological clearance in adults hospitalized with mild COVID-19.
Randomized, double-blind, placebo-controlled trial conducted among 72 hospitalized adult patients with SARS-CoV-2 in Dhaka, Bangladesh.
Patients were randomized into three arms: oral ivermectin alone (12 mg daily for 5 days), oral ivermectin plus doxycycline (12 mg single dose and doxycycline for 5 days), or placebo control.
Virological clearance occurred significantly earlier in the 5-day ivermectin arm compared to the placebo group (9.7 days vs 12.7 days; p = 0.02).
Virological clearance in the ivermectin plus doxycycline arm did not differ significantly from placebo (11.5 days vs 12.7 days; p = 0.27).
Clinical symptoms including fever, cough, and sore throat were comparable among the three groups, with no severe adverse drug events recorded.

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Implication

Randomized double-blind trial shows faster virological clearance with five-day ivermectin in mild COVID-19, suggesting potential utility in shortening viral shedding.

Cite This Study

Ahmed et al. (2020) studied this question.

synapsesocial.com/papers/69dcf8128cc25b5e451333f7 https://doi.org/10.1016/j.ijid.2020.11.191

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Implication

Randomized double-blind trial shows faster virological clearance with five-day ivermectin in mild COVID-19, suggesting potential utility in shortening viral shedding.

A five-day course of ivermectin for the treatment of COVID-19 may reduce the duration of illness

Key Points

Discussion

Implication

Cite This Study

A five-day course of ivermectin for the treatment of COVID-19 may reduce the duration of illness

Key Points

Discussion

Implication

Cite This Study