Clinical study demonstrates intravenous fluid volume independently links to glycocalyx degradation in sepsis, suggesting fluid resuscitation may induce iatrogenic endothelial injury.
Glycocalyx degradation occurs in sepsis and septic shock and is associated with in-hospital mortality. The volume of intravenous fluids administered during sepsis resuscitation is independently associated with the degree of glycocalyx degradation. These findings suggest a potential mechanism by which intravenous fluid resuscitation strategies may induce iatrogenic endothelial injury.
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Hippensteel et al. (2019) studied this question.
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