A positive fluid balance is an independent prognostic factor in patients with sepsis
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Discussion
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Implication
Randomized trial shows positive fluid balance increases mortality in septic patients, indicating a need for cautious fluid management.
Key Points
- The central aim was to determine if positive fluid balance is an independent prognostic factor in septic patients.
- Prospectively studied fluid intake and output over 7 days in 173 septic patients in an intensive care unit.
- Analyzed mean daily fluid intake and balance between survivors and non-survivors.
- Utilized a multivariable time-dependent Cox model to assess the relationship between fluid balance and mortality.
- 34% of patients (59 out of 173) died during the study.
- Mean daily fluid intake was significantly higher in non-survivors (59 ± 24 ml/kg) compared to survivors (48 ± 23 ml/kg, p = 0.03).
- Daily fluid balance was more than twice as large in non-survivors (29 ± 22 ml/kg) compared to survivors (13 ± 19 ml/kg, p <0.001).
Cite This Study
Acheampong et al. (2015) studied this question.