Analysis of massive PE cases reveals thrombolysis and IVC filters may not improve outcomes, suggesting need for reevaluation.
In ICOPER, two thirds of the patients with massive PE did not receive thrombolysis or embolectomy. Counterintuitively, thrombolysis did not reduce mortality or recurrent PE at 90 days. The observed reduction in mortality from IVC filters requires further investigation.
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Kucher et al. (2006) studied this question.
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