Why the study?
Does a five-drug chemotherapy regimen increase the incidence of thrombosis in patients with Stage IV breast carcinoma?
Population
159 patients with Stage IV breast carcinoma. A subset of 10 patients and 10 controls were included in…
Comparison
Five-drug chemotherapy regimen vs Periods off the chemotherapy regimen and 10…
Design
Cohort
Authors
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Chemotherapy was associated with higher thrombosis risk in stage IV breast cancer; hypothesis-generating for Factor VIII as mediator, warranting prospective confirmation.
Does a five-drug chemotherapy regimen increase the incidence of thrombosis in patients with Stage IV breast carcinoma?
A five-drug chemotherapy regimen for Stage IV breast cancer is associated with a significantly increased risk of thromboembolism, potentially mediated by a hypercoagulable state.
Goodnough et al. (1984) studied this question.
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