HPeV type 3 is a significant cause of severe sepsis and fever with CNS involvement in young infants.
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Supports HPeV testing in young infants with sepsis or CNS involvement; leaves open prospective studies to guide practice.
HPeV was a significant cause of severe sepsis and fever with central nervous system involvement in young infants, rivaling enteroviruses. The specific targeting of young infants by HPeV type 3 may reflect a difference in tissue tropism between virus types or a lack of protection of young infants by maternal antibody consequent to the recent emergence of HPeV.
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Harvala et al. (2009) studied this question.
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