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Establish a large-scale canine genomic reference dataset to characterize demographic history, genetic architecture, and functional variation across canids.

August 15, 2023Genome biologyOpen Access

Genome sequencing of 2000 canids by the Dog10K consortium advances the understanding of demography, genome function and architecture

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Establish a large-scale canine genomic reference dataset to characterize demographic history, genetic architecture, and functional variation across canids.
Generated high-coverage whole-genome sequencing data from 1,987 canids via the Dog10K consortium.
Evaluated patterns of allele sharing, cataloged likely functional sequence variants, and constructed imputation reference panels.
Resolved fine-scale population and breed structures across domestic dogs and wild canid lineages.
Demonstrated accurate genotype imputation capabilities using the public reference panel of 1,987 sequenced canids.

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Implication

Genome sequencing study uncovers allele sharing and functional variants in canids, highlighting breed architecture and supporting genetic imputation.

Cite This Study

Meadows et al. (2023) studied this question.

synapsesocial.com/papers/69dd1bfad111c0385b359dec https://doi.org/10.1186/s13059-023-03023-7

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Implication

Genome sequencing study uncovers allele sharing and functional variants in canids, highlighting breed architecture and supporting genetic imputation.

Genome sequencing of 2000 canids by the Dog10K consortium advances the understanding of demography, genome function and architecture

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Discussion

Implication

Cite This Study

Genome sequencing of 2000 canids by the Dog10K consortium advances the understanding of demography, genome function and architecture

Key Points

Discussion

Implication

Cite This Study

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