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April 1, 2001Journal of Clinical InvestigationOpen Access

A COL1A1 Sp1 binding site polymorphism predisposes to osteoporotic fracture by affecting bone density and quality

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VMVal MannUniversity of PlymouthEHEmma E. HobsonSt James's University HospitalBLBaohua LiBinzhou University

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Mann et al. (2001) studied this question.

synapsesocial.com/papers/69dd1c45854f360ad63599f3https://doi.org/10.1172/jci10347
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1An Sp1 Binding Site Polymorphism in the COLIA1 Gene Predicts Osteoporotic Fractures in Both Men and Women1998 · 167 citations
  2. 2Relation of Alleles of the Collagen Type Iα1 Gene to Bone Density and the Risk of Osteoporotic Fractures in Postmenopausal Women1998 · 424 citations
  3. 3Analysis of gene expression in human bone biopsies by polymerase chain reaction: Evidence for enhanced cytokine expression in postmenopausal osteoporosis1994 · 177 citations