Why the study?
Does oral contraceptive use affect the corrected QT interval?
Does oral contraceptive use affect the corrected QT interval?
Fourth generation oral contraceptives may lengthen the QTc interval, highlighting a potential need for careful monitoring of adverse events in these users.
Fourth-generation OC use was associated with QTc prolongation; hypothesis-generating for arrhythmic risk and needs prospective confirmation.
Overall, OC use has a shortening effect on the QTc. Shorter QTc is seen with first and second generation OC while fourth generation OC use has a lengthening effect on the QTc. Careful examination of adverse event rates in fourth generation OC users is needed.
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Sedlak et al. (2013) studied this question.
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