What does this research mean for the field?

QTc prolongation measured by standard 12-lead electrocardiography is an independent risk factor for sudden death in patients without cardiac dysfunction, but not in those with existing cardiac dysfunction. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

June 1, 1991Circulation

QTc prolongation measured by standard 12-lead electrocardiography is an independent risk factor for sudden death due to cardiac arrest.

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Why the study?

Does QTc prolongation measured by standard 12-lead ECG increase the risk of sudden death in patients undergoing ambulatory ECG?

Structured PICO

Does QTc prolongation measured by standard 12-lead ECG increase the risk of sudden death in patients undergoing ambulatory ECG?

Population

6,693 consecutive patients who underwent 24-hour ambulatory electrocardiography (Rotterdam QT Project), specifically analyzing a subset of 176 patients who died suddenly and 390 random sample patients without intraventricular conduction defects.

Intervention

QTc prolongation (> 440 msec) measured by standard 12-lead electrocardiogram

Comparator

Normal QTc (≤ 440 msec)

Outcome

Sudden death due to cardiac arrest at 2 years follow-uphard clinical

QTc prolongation > 440 msec on a standard 12-lead ECG is an independent risk factor for sudden death specifically in patients without underlying cardiac dysfunction or intraventricular conduction defects.

Discussion

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Implication

Prolonged QTc may flag higher sudden death risk without cardiac dysfunction; extends conflicting observational data but should not yet change practice.

Cite This Study

Algra et al. (1991) studied this question.

synapsesocial.com/papers/6a1769a41b114e5976b40585 https://doi.org/10.1161/01.cir.83.6.1888

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Implication

Prolonged QTc may flag higher sudden death risk without cardiac dysfunction; extends conflicting observational data but should not yet change practice.

QTc prolongation measured by standard 12-lead electrocardiography is an independent risk factor for sudden death due to cardiac arrest.

Structured PICO

Discussion

Implication

Cite This Study

QTc prolongation measured by standard 12-lead electrocardiography is an independent risk factor for sudden death due to cardiac arrest.

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider