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December 16, 2009Proceedings of the National Academy of SciencesOpen Access

Positive selection identifies an in vivo role for FimH during urinary tract infection in addition to mannose binding

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SCSwaine L. ChenGenome Institute of SingaporeCHChia‐Suei HungUnited States Air Force Research LaboratoryJPJerome S. PinknerWashington University in St. Louis

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Chen et al. (2009) studied this question.

synapsesocial.com/papers/69dd1c7c5f91138675359dd5https://doi.org/10.1073/pnas.0902179106
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Type 1 fimbrial expression enhances Escherichia coli virulence for the urinary tract.1996 · 740 citations
  2. 2Induction and Evasion of Host Defenses by Type 1-Piliated Uropathogenic Escherichia Coli1999 · 285 citations
  3. 3Host-Symbiont Conflicts: Positive Selection on an Outer Membrane Protein of Parasitic but not Mutualistic Rickettsiaceae2002 · 109 citations
  4. 4Differential Stability and Trade-Off Effects of Pathoadaptive Mutations in the Escherichia coli FimH Adhesin2007 · 74 citations
  5. 5Escherichia coli from Urine of Female Patients with Urinary Tract Infections Is Competent for Intracellular Bacterial Community Formation2006 · 163 citations