May 30, 2007Pain
Peripheral and central components of habituation of heat pain perception and evoked potentials in humans
Why the study?
Does repetitive noxious heat stimulation at a fixed location compared to variable locations alter heat pain perception and evoked potentials in volunteers?
Population
16 volunteers
Comparison
Repetitive brief noxious heat stimuli applied to… vs Repetitive brief noxious heat stimuli applied to…
Design
Other
Authors
Discussion
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Implication
Fixed-location heat may accelerate habituation in pain experiments; leaves open effects on clinical nociceptive testing protocols.
Structured PICO
Does repetitive noxious heat stimulation at a fixed location compared to variable locations alter heat pain perception and evoked potentials in volunteers?
P
Population
16 volunteers
I
Intervention
Repetitive brief noxious heat stimuli applied to the right forearm at a fixed location (inter-stimulus intervals 8-10s)
C
Comparator
Repetitive brief noxious heat stimuli applied to variable locations
O
Outcome
Heat pain ratings and contact-heat evoked potentials (N1 and N2-P2 components)surrogate
Human heat pain perception and contact-heat EPs display rapid habituation when stimulation is restricted to a fixed location, reflecting fatigue of peripheral nociceptive neurons.
Cite This Study
Greffrath et al. (2007) studied this question.