What question did this study set out to answer?

To establish a comprehensive multi-organ single-cell transcriptomic atlas of the human body to systematically characterize cell types and tissue-specific gene regulation.

May 12, 2022ScienceOpen Access

The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans

View Full Paper

Ask AI

Bookmark

To establish a comprehensive multi-organ single-cell transcriptomic atlas of the human body to systematically characterize cell types and tissue-specific gene regulation.
Generated a single-cell transcriptomic reference atlas encompassing nearly 500,000 cells across 24 distinct human tissues and organs, with multiple tissues obtained from the same donor.
Profiled gene expression, cell cycle states, RNA splicing variants, and immune repertoire features to characterize cellular diversity and distribution across tissues.
Classified and molecularly characterized more than 400 distinct cell types and mapped their cross-tissue distributions and gene expression variations.
Identified cross-tissue clonal distributions of T cells and tissue-specific somatic mutation rates in B cells using multi-tissue donor sampling.
Discovered cell-type-specific and tissue-dependent alternative RNA splicing patterns across organs within the same individual.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Single-cell transcriptomic profiling reveals distinct gene expression and clonal distributions across 24 human organs, highlighting shared and tissue-specific cell features within individuals.

Cite This Study

Jones et al. (2022) studied this question.

synapsesocial.com/papers/69dd1d1bbc2a1a5f64e52ce8 https://doi.org/10.1126/science.abl4896

View Full Paper

Ask AI

Bookmark

Implication

Single-cell transcriptomic profiling reveals distinct gene expression and clonal distributions across 24 human organs, highlighting shared and tissue-specific cell features within individuals.

The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans

Key Points

Discussion

Implication

Cite This Study

The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans

Key Points

Discussion

Implication

Cite This Study

Keep reading

Keep reading