What question did this study set out to answer?

To determine whether postnatal microbial colonization influences the development of brain plasticity and endocrine hypothalamic-pituitary-adrenal (HPA) stress reactivity.

May 10, 2004The Journal of PhysiologyOpen Access

Postnatal microbial colonization programs the hypothalamic–pituitary–adrenal system for stress response in mice

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Authors

NSNobuyuki SudoKyushu University YCYoichi ChidaKyushu University YAYuji AibaTokai University

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Implication

Preclinical study reveals that early microbial colonization regulates hypothalamic-pituitary-adrenal stress responses in mice, indicating a critical developmental window for neural regulation.

Key Points

To determine whether postnatal microbial colonization influences the development of brain plasticity and endocrine hypothalamic-pituitary-adrenal (HPA) stress reactivity.
Compared plasma ACTH and corticosterone elevations under restraint stress and ether stimulation in germ-free, specific pathogen-free, and gnotobiotic mice.
Measured BDNF expression levels in the cortex and hippocampus across germ-free and specific pathogen-free groups.
Reconstituted germ-free mice with Bifidobacterium infantis, enteropathogenic Escherichia coli, or specific pathogen-free faeces at early versus late developmental stages.
Germ-free mice demonstrated substantially greater plasma ACTH and corticosterone elevations following restraint stress and lower cortical and hippocampal BDNF expression than specific pathogen-free mice.
Exaggerated HPA reactivity in germ-free mice was reversed by monoassociation with Bifidobacterium infantis, while enteropathogenic E. coli colonization enhanced stress responses.
Early-stage reconstitution with specific pathogen-free faeces partially corrected the enhanced HPA stress response, whereas late-stage reconstitution failed to reverse HPA hyperactivity.

Cite This Study

Sudo et al. (2004) studied this question.

synapsesocial.com/papers/69dd1e56bc2a1a5f64e52d4f https://doi.org/10.1113/jphysiol.2004.063388

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Implication

Preclinical study reveals that early microbial colonization regulates hypothalamic-pituitary-adrenal stress responses in mice, indicating a critical developmental window for neural regulation.

Postnatal microbial colonization programs the hypothalamic–pituitary–adrenal system for stress response in mice

Discussion

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Implication

Key Points

Cite This Study

Postnatal microbial colonization programs the hypothalamic–pituitary–adrenal system for stress response in mice

Discussion

Member takes

Implication

Key Points

Cite This Study

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