Do EPA and DHA improve vascular reactivity of the forearm microcirculation in hyperlipidemic, overweight men compared to placebo?
DHA, but not EPA, improves endothelium-independent vasodilator mechanisms and attenuates constrictor responses in the forearm microcirculation, potentially explaining its selective blood pressure-lowering effects.
Relative to placebo, DHA, but not EPA, enhances vasodilator mechanisms and attenuates constrictor responses in the forearm microcirculation. Improvements in endothelium-independent mechanisms appear to be predominant and may contribute to the selective blood pressure-lowering effect observed with DHA compared with EPA in humans.
Mori et al. (Tue,) studied this question.