Why the study?
Do EPA and DHA improve vascular reactivity of the forearm microcirculation in hyperlipidemic, overweight men compared to placebo?
Do EPA and DHA improve vascular reactivity of the forearm microcirculation in hyperlipidemic, overweight men compared to placebo?
DHA, but not EPA, improves endothelium-independent vasodilator mechanisms and attenuates constrictor responses in the forearm microcirculation, potentially explaining its selective blood pressure-lowering effects.
DHA may confer microvascular benefits absent with EPA in hyperlipidemic men; extends evidence for omega-3 subtype specificity in vascular function.
Relative to placebo, DHA, but not EPA, enhances vasodilator mechanisms and attenuates constrictor responses in the forearm microcirculation. Improvements in endothelium-independent mechanisms appear to be predominant and may contribute to the selective blood pressure-lowering effect observed with DHA compared with EPA in humans.
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Mori et al. (2000) studied this question.