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August 22, 2012JAMAOpen Access

Common Carotid Intima-Media Thickness Measurements in Cardiovascular Risk Prediction

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Why the study?

Does the addition of common CIMT measurements to the Framingham Risk Score improve 10-year risk prediction of first-time myocardial infarction or stroke?

Population

Individuals assessed for cardiovascular risk

Comparison

Addition of common carotid intima-media… vs Framingham Risk Score alone

Follow-up

10 years

Authors

HRHester M. den RuijterPreventive CardiologySPSanne A. E. PetersPreventive CardiologyTATodd J. AndersonInterventional Cardiology

Discussion

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Member takes

Overview

Does not support adding CIMT to Framingham Risk Score in practice; leaves open whether other markers improve prediction.

Structured PICO

Does the addition of common CIMT measurements to the Framingham Risk Score improve 10-year risk prediction of first-time myocardial infarction or stroke?

P
Population
Individuals assessed for cardiovascular risk
I
Intervention
Addition of common carotid intima-media thickness (CIMT) measurements to the Framingham Risk Score
C
Comparator
Framingham Risk Score alone
O
Outcome
10-year risk prediction of first-time myocardial infarction or stroke

Adding common CIMT measurements to the Framingham Risk Score provides only a small, clinically unimportant improvement in predicting 10-year risk of first-time MI or stroke.

Cite This Study

Ruijter et al. (2012) studied this question.

synapsesocial.com/papers/69dd358b7808b00a4799b708https://doi.org/10.1001/jama.2012.9630
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Arterial Stiffness Increases With Deteriorating Glucose Tolerance Status2003 · 472 citations
  2. 2Carotid Intima-Media Thickness and Presence or Absence of Plaque Improves Prediction of Coronary Heart Disease Risk. The ARIC (Atherosclerosis Risk In Communities) Study2020 · 77 citations