September 19, 2011Heart
Effects of age on long-term outcomes after a routine invasive or selective invasive strategy in patients presenting with non-ST segment elevation acute coronary syndromes: a collaborative analysis of individual data from the FRISC II - ICTUS - RITA-3 (FIR) trials
Why the study?
Does a routine invasive strategy improve long-term outcomes compared to a selective invasive strategy in patients presenting with non-ST segment elevation acute coronary syndromes?
Population
Patients presenting with non-ST segment elevation acute coronary syndromes from the FRISC II, ICTUS, and…
Comparison
Routine invasive strategy vs Selective invasive strategy
Design
Meta-analysis
Follow-up
long-term
Authors
Discussion
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Member takes
Implication
May favor selective over routine invasive strategy in younger patients and women; extends evidence for age- and sex-specific NSTE-ACS management.
Structured PICO
Does a routine invasive strategy improve long-term outcomes compared to a selective invasive strategy in patients presenting with non-ST segment elevation acute coronary syndromes?
P
Population
Patients presenting with non-ST segment elevation acute coronary syndromes (NSTE-ACS) from the FRISC II, ICTUS, and RITA-3 trials
I
Intervention
Routine invasive strategy
C
Comparator
Selective invasive strategy
O
Outcome
Long-term outcomes including long-term cardiovascular mortalityhard clinical
The long-term benefit of a routine invasive strategy in NSTE-ACS is attenuated in patients <65 years and women due to early events, though without consequence for long-term cardiovascular mortality.
Cite This Study
Damman et al. (2011) studied this question.