What question did this study set out to answer?

To evaluate peripheral blood glial fibrillary acidic protein (GFAP) as a diagnostic and prognostic biomarker for Alzheimer's disease.

May 4, 2023CellsOpen Access

GFAP as a Potential Biomarker for Alzheimer’s Disease: A Systematic Review and Meta-Analysis

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Authors

KKKa Young KimKyung Hee University KSKi Young ShinCenter for the Study of Community Colleges KCKeun‐A ChangGachon University

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Implication

Systematic review and meta-analysis reveals elevated blood GFAP in individuals with Alzheimer's disease and mild cognitive impairment, indicating its diagnostic utility.

Key Points

To evaluate peripheral blood glial fibrillary acidic protein (GFAP) as a diagnostic and prognostic biomarker for Alzheimer's disease.
Conducted a systematic review and meta-analysis synthesizing clinical evidence on blood GFAP concentrations.
Analyzed peripheral blood GFAP levels across amyloid-β status cohorts and between healthy controls and individuals with mild cognitive impairment or Alzheimer's disease.
Blood GFAP concentrations are elevated in amyloid-β-positive cohorts relative to amyloid-β-negative groups.
Circulating GFAP levels are higher in individuals diagnosed with mild cognitive impairment or Alzheimer's disease compared to healthy controls.

Cite This Study

Kim et al. (2023) studied this question.

synapsesocial.com/papers/69dd3e7ffb7610310c101396 https://doi.org/10.3390/cells12091309

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Implication

Systematic review and meta-analysis reveals elevated blood GFAP in individuals with Alzheimer's disease and mild cognitive impairment, indicating its diagnostic utility.

GFAP as a Potential Biomarker for Alzheimer’s Disease: A Systematic Review and Meta-Analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

GFAP as a Potential Biomarker for Alzheimer’s Disease: A Systematic Review and Meta-Analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

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